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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN12 All Species: 22.42
Human Site: Y64 Identified Species: 49.33
UniProt: Q05209 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05209 NP_001124480.1 780 88120 Y64 E N V K K N R Y K D I L P F D
Chimpanzee Pan troglodytes XP_519168 792 88529 Y76 E N V K K N R Y K D I L P F D
Rhesus Macaque Macaca mulatta XP_001082837 733 82786 E54 I Y P T A T G E K E E N V K K
Dog Lupus familis XP_540396 757 85032 R48 I L P F D H S R V K L T L K T
Cat Felis silvestris
Mouse Mus musculus P35831 775 86973 Y64 E N V K K N R Y K D I L P F D
Rat Rattus norvegicus NP_476456 766 85965 Y64 E N V K K N R Y K D I L P F D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507461 747 83881 R50 I L P F D H S R V K L T L K T
Chicken Gallus gallus XP_415970 1211 131521 Y487 E N V K K N R Y K D I L P F D
Frog Xenopus laevis NP_001084841 660 74123
Zebra Danio Brachydanio rerio NP_956963 570 64484
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796904 967 106580 Y66 V N M R K N R Y K D I L P F D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 91.4 88 N.A. 82.8 83.5 N.A. 74.6 48.3 58.2 46.7 N.A. N.A. N.A. N.A. 28.9
Protein Similarity: 100 95.4 92.3 91 N.A. 88.3 88.8 N.A. 81.1 53.5 66.9 57.4 N.A. N.A. N.A. N.A. 44
P-Site Identity: 100 100 6.6 0 N.A. 100 100 N.A. 0 100 0 0 N.A. N.A. N.A. N.A. 80
P-Site Similarity: 100 100 13.3 13.3 N.A. 100 100 N.A. 13.3 100 0 0 N.A. N.A. N.A. N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 19 0 0 0 0 55 0 0 0 0 55 % D
% Glu: 46 0 0 0 0 0 0 10 0 10 10 0 0 0 0 % E
% Phe: 0 0 0 19 0 0 0 0 0 0 0 0 0 55 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 19 0 0 0 0 0 0 0 0 0 % H
% Ile: 28 0 0 0 0 0 0 0 0 0 55 0 0 0 0 % I
% Lys: 0 0 0 46 55 0 0 0 64 19 0 0 0 28 10 % K
% Leu: 0 19 0 0 0 0 0 0 0 0 19 55 19 0 0 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 55 0 0 0 55 0 0 0 0 0 10 0 0 0 % N
% Pro: 0 0 28 0 0 0 0 0 0 0 0 0 55 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 10 0 0 55 19 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 19 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 10 0 10 0 0 0 0 0 19 0 0 19 % T
% Val: 10 0 46 0 0 0 0 0 19 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 0 55 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _